INR Study


This study will examine immunologic differences in lymph node biopsy samples between those who have had a good CD4 increase after taking HIV medications compared to those who have had a poor CD4 increase after taking HIV medications. The researchers are interested in determining if differences exist between these groups as these might be a potential target for the development of an HIV vaccine or treatment to improve CD4 responses for all individuals receiving HIV treatment and thereby increase survival and quality of life.  By testing a radically innovative hypothesis, these studies will provide unprecedented, novel insights into the mechanism underlying the quality of the immunological response to antiretroviral therapy (ART) and the resulting size/persistence of the HIV reservoir in People living with HIV (PLHIV). If our hypothesis is confirmed, these studies will suggest that novel strategies aimed at protecting CD4 TCM (Central Memory T cells) from infection should be a critical component of interventions aimed at curing HIV infection. For this protocol, participants will have a biopsy of an inguinal LN. All blood specimens will be obtained through a separate protocol.


The study involves two (2) study visits. During the first visit, you will be explained the study, sign a consent form and have some blood drawn. During the second visit, the surgeon will remove a single lymph node (LN) from your right or left groin (inguinal area). To do this, the surgeon will make a small cut in the inguinal area and identify the lymph node to be removed. He or she will then carefully remove the lymph node. Your surgeon will close the cut with dissolvable stitches. This visit may take up to 4 hours. At that visit you will be for consented and explained the procedures. Your medical history will be reviewed by the study staff and a physical examination will be performed to check your eligibility for this study. You will only be eligible if you are HIV positive.

Who can participate?

We are seeking adults who are HIV positive and have undetectable Viral Loads. 

To learn more contact

Theron Stuart at or 404-727-8987